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Looking for the most economical way to get from Rome to Civitavecchia Port. Also would like recommendations for a hotel in Rome for the night before the cruise

Are you going from downtown Rome or from the airport? As you're probably aware. the port is to the north from the city. Try this link to see your options.
As to hotel, if you decide to take the train from the main train station in Rome (Termini), it would be best to find a hotel near the station. This a a HUGE station, so I'd suggest you familiarize yourself with it ahead of time. That area is also a good touring base.

From Downtown Rome. The link you gave me was very helpful. Has anyone used UBER in Rome?